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Targeting Serotonin Transporters for the Treatment of L-DOPA-induced Dyskinesia
… treatment leads to abnormal involuntary movements known as dyskinesia. In recent years, compelling evidence has … play an integral role in expression of levodopa-induced dyskinesia. Preclinical studies of the current project will … selective serotonin reuptake inhibitors (SSRIs) reduces dyskinesia, while maintaining levodopa efficacy implicating …
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The Nur77/RXR Transcriptional Complex as a New Target in L-Dopa-induced Dyskinesia Treatment
… processes such as those occurring in levodopa-induced dyskinesias. We have previously shown that two transcription … Nur77 and RXR can be targeted to reduce levodopa-induced dyskinesias. Project Description: To demonstrate the role of … Parkinson’s disease treated with levodopa. Levodopa-induced dyskinesias will be evaluated using the rotational response, …
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Development of L-745,870, a Selective D4 Receptor Antagonist, for the Treatment of Levodopa-induced Dyskinesia
… that L-745,870 reduces the problem of levodopa-induced dyskinesia in pre-clinical models with parkinsonism. We … of L-745,870 and move it forward as a treatment for dyskinesia in PD. Project Description: We have … Parkinson’s Disease: Levodopa-induced dyskinesia remains one of the major factors limiting the …
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Evaluation of Cortical Resonant Oscillations as a Novel Target for Treatment of Dyskinesia
… that when parkinsonian models experience levodopa-induced dyskinesia this is always associated with high-frequency … with the oscillation in order to reduce levodopa-induced dyskinesia. Because activity in one part of the brain often … of the physiological mechanisms causing levodopa-induced dyskinesia and may suggest novel future targets for …
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Targeting M4 Muscarinic Receptors for the Treatment of Levodopa-induced Dyskinesia
… Study Rationale: Levodopa-induced dyskinesia is thought to stem from sustained stimulation of … adjunct therapies that alleviate levodopa-induced dyskinesia. Next Steps for Development: Any insights gained … … Glutamate Receptors … Neuropharmacology … Illinois … Dyskinesia … Dyskinesia Challenge … Weixing Shen PhD, PhD … …
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Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
… Objective/Rationale: Dyskinesia is a term used to describe involuntary movements … of dopamine drugs used to treat Parkinson's disease. Dyskinesias are frequent and disabling to many … of daily living. Currently, among medications to treat dyskinesia, only amantadine is effective and readily …