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Neuroprotective Effects of A2A Antagonists in Rodent Models of Motor Function and Dyskinesia
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Effect of glycine transporter 1 inhibition with bitopertin on parkinsonism and L-DOPA induced dyskinesia in the 6-OHDA-lesioned rat
August 15, 2022
… Dyskinesia remains an unmet need in Parkinson's disease … transporter 1 (GlyT1) inhibition with ALX-5407 reduces dyskinesia and slightly improves parkinsonism in the …
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Pilot Assessment of the Effect of Optimism and Expectation on Dyskinesia Rating Scales in Parkinson's Disease Subjects Randomized to Placebo or Amantadine
… investigator expectation of positive outcome on various dyskinesia rating scale used in a double-blind, … placebo-controlled study of amantadine treatment for dyskinesia in PD. Additionally, we will gather information …
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“For patients, a better solution cannot come quickly enough” — Wall Street Journal Reports on Progress in Dyskinesia Research
March 26, 2013
… reports on promising new research directions to treat dyskinesia (subscription required), the disabling side … effect or attenuate the movement side effects, called dyskinesia, that come with the drug, levodopa. […] “The …
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Highly-selective μ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model
March 12, 2020
… (PD), but often leads to development of L-DOPA-induced dyskinesia (LID), which can be as debilitating as the motor …
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The delta-specific opioid glycopeptide BBI-11008: CNS penetration and behavioral analysis in a preclinical model of levodopa-induced dyskinesia
December 18, 2020
… of Parkinson's disease (PD) and levodopa (L-DOPA)-induced dyskinesia (LID). In the present study, we tested the …