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Safety and Tolerability of NLX-112 in People with Parkinson’s
… side effects such as uncontrolled jerky movements, called dyskinesia, that negatively impact quality of life. Recent studies show that dyskinesia is associated with another brain …
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Anti-dyskinetic Activity of the Selective 5-HT1A Agonist NLX-112: Behavioral and Microdialysis Studies
… receptor subtype is an attractive strategy to decrease the dyskinesia that arises in Parkinson’s disease (PD) patients … selective drug (NLX-112) completely abolished the dyskinesia-like symptoms observed in pre-clinical …
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A Small Molecule Approach to Correct Striatal Cholinergic Interneuron Dysfunction
… their hyperactivation under conditions of levodopa induced dyskinesia (LID). We propose here an approach to precisely … study in PD patients with LID using this small molecule. … Dyskinesia … Neuropharmacology … Rapid Response Innovation …
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Investigation of PDE10a Inhibitors for Parkinsons Disease.PI is Bart Ellenbroek
… the treatment of PD or for the treatment of L-DOPA induced dyskinesias. Project Description : In part 1, we will … whether this PDE10A is effective in counteracting the dyskinesias seen after repeated treatment with L-DOPA in the …
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Modulation of Striatal Colinergic Neuronal Activity in LID
… disease and side effects of treatment like levodopa-induced dyskinesia (LID) have been poorly studied. We have recently … treatment and determining if it prevents levodopa-induced dyskinesia. We employed a novel approach to kill striatal …
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Pharmacokinetics and Cognitive Side Effects of the Antidyskinetic Drug Fenobam in MPTP-treated Pre-clinical Models
… Prodrug of Acamprosate for Treatment of L-DOPA-Induced Dyskinesias Promising Outcomes of Original Grant : The goal …