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Metal Complexation with Levodopa to Improve Continuous Dopaminergic Stimulation
… pulsatility is expected to result in a lower incidence of dyskinesia and off-periods down the road. For late-stage … work leading to an IND application will now be pursued. … Dyskinesia … Neuropharmacology … Virginia … United States … …
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Development of Novel Phosphodiesterase Inhibitors for the Symptoms & Side Effects Treatment of Parkinson's Disease
… and induces uncontrolled motor dysregulation, known as dyskinesia, after prolonged use. Thus, adjunct treatments … with lower doses of levodopa and reducing the incidence of dyskinesias. In collaboration with colleagues at The …
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The Role of Casein Kinase 2 in the Modulation of Dopamine Signaling in Parkinson's Disease
… decreases and side effects including cognitive deficits and dyskinesia increase. This is thought to be due to adaptive … as well as in the L-Dopa-induced side effects such as dyskinesia. We will study the role of CK2 by using mice with …
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Identifying Markers of PD Onset and Progression in a Prospective Cohort of Patients and ASymptoms & Side Effects Carriers of LRRK2 Mutations
… the power of statistical and correlation analyses. … Dyskinesia … Clinical Trial … Austria … Research Grant … …
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Predicting Cognitive Profiles in Parkinson's Disease: A Multimodal Approach
… for when the participants were seen at 18 months. … Dyskinesia … Clinical Trial … France … Defining Cognitive …
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Preferential Targeting of Subpopulations of 5-HT1A Receptors: Microdialysis Study
… candidate will be taken forward into clinical trials. … Dyskinesia … Neuropharmacology … Serotonin receptors … …