… measure for testing patient response to therapies to treat dyskinesia, the debilitating, uncontrollable movements that … effect of Parkinson’s disease (PD) drugs. MJFF has made dyskinesia a top research priority due to its significant … the United States, Canada and Europe, show that the Unified Dyskinesia Rating Scale (UDysRS) is superior to other tested …

… “for patients, a better solution cannot come soon enough.” (Subscription required) Holly Teichholtz Chief Marketing …

… treatment, thus delaying the onset of sensitization and dyskinesia.  Project Description: This project has been … and the potential risk that a DAMA compound may elicit dyskinesia in a pre-clinical model of PD. If findings show … efficacy as well as levodopa-sparing potential and anti-dyskinesia activity. Relevance to Diagnosis/Treatment of …

… development of uncontrollable involuntary movements, called dyskinesia. In addition, the benefits conferred by levodopa … adequately address the symptoms of PD without exacerbating dyskinesia. Many people with advanced PD also experience … of a brain chemical called glycine could alleviate dyskinesia and psychosis, while also improving the symptoms …

… (PD), it has a debilitating on-target side effect of dyskinesia. An optimal PD therapy would selectively activate … of dopamine receptors while avoiding those that induce dyskinesia. Using machine learning algorithms developed by … has been shown to robustly reduce both PD symptoms and dyskinesia when administered with levodopa. Hypothesis: …

… Development of their dyskinesia drug continues Michael J. Fox Foundation (MJFF) … to the development of dipraglurant as a treatment for dyskinesia in Parkinson’s disease.  “The data and partnering … of dipraglurant in the treatment of PD levodopa-induced dyskinesia,” says Addex CEO Bharatt Chowira. In its …