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Selective Inhibition of Cyclic Nucleotide Phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease
… side effects including abnormal involuntary movements, or dyskinesias. There is therefore a continual search for novel … in non-human primate models of PD while causing less dyskinesia than does levodopa. Project Description: We will … for ability to improve motor symptoms with a minimum of dyskinesias. The optimal dose and timing of treatment will …
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Addex Therapeutics Awarded $1 MM Grant from The Michael J. Fox Foundation for Parkinson's Research
March 19, 2013
… for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID). One-third of people with PD develop dyskinesia within four to six years of beginning levodopa … cause of disability in this growing patient population. "Dyskinesia is a top priority for our Foundation because of …
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Ask the MD: What Off, On and Other Common Parkinson’s Terms Mean
September 17, 2021
… (PD), you’ve probably come across words like “off,” “on,” dyskinesia and others. These describe certain Parkinson’s … control. This is when you have little or no symptoms. Dyskinesia : involuntary movement. Dyskinesia is extra movement, such as twisting and turning …
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Addex Adds It Up for Parkinson's Patients
March 21, 2012
… needs for those living with Parkinson’s disease today — dyskinesia. Swiss biotech Addex Therapeutics announced … in Parkinson's disease. But levodopa can also lead to dyskinesia, the uncontrollable movements that are a … to experience the benefits of levodopa while limiting dyskinesia. MJFF spoke with Bill Langston, MD, scientific …
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Another Drug for Parkinson's Gets Approval
March 8, 2018
… in early Parkinson's. But doctors often prescribe it for dyskinesia (involuntary, uncontrolled movements) even though … once-a-day formulation is FDA-approved for the treatment of dyskinesia, “off” time (when symptoms are not controlled) or … that the medication levels are highest during the day, when dyskinesia and other symptoms typically are most bothersome. …
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Highlights from the American Academy of Neurology Annual Meeting
March 20, 2013
… disease is that slowing D1’s activity could help to reduce dyskinesia . One company presenting this week at AAN called … amantadine, often prescribed off-label for levodopa-induced dyskinesias, does not delay the onset of this troublesome … after beginning such a regimen had the same rate of dyskinesia. The study was not designed to measure whether …