… (Shh) pathway could be utilized to regulate GDNF expression from endogenous sources in the adult brain. We wish to test … trials as anticancer treatments. Hence positive results from this proof of principle study could be translated … MPTP and/or increased recovery of dopamine neurons from the neurotoxic insult. Progress Report GDNF is a potent …

… method will be used to analyze the data generated from in vivo imaging and the analysis of biological fluids … parameters for an appropriate scale-up of drug distribution from a model brain to the human brain. Progress Report The team has switched from I-125 labeled DN-TNF to instead pursuing gadolinium …

… This grant builds upon the research from a prior grant: CSF Lysosomal Hydrolases' Activity as … (-20°C vs – 80°C); (iv) intra-assay (10 triplicate aliquots from the same CSF sample) and inter-assay precision (10 runs … and synuclein oligomers allows us to distinguish PD from neurological controls. The accurate knowledge of …

… the patient. To accomplish both these goals, a fragment from an antibody that detects alpha-synuclein will be linked … currently no accurate way to diagnose Parkinson’s disease from MRI imaging. Although some biomarkers for Parkinson’s … accessibility to diagnosis for patients who live far from clinical centers. Further, although research has shown …

… disease (PD). Parkin is an enzyme that tags proteins from damaged mitochondria with ubiquitin (a small protein) … Activation of Parkin ubiquitin ligase activity results from a three-dimensional (3D) rearrangement within the … block of proteins), ready for the ubiquitin transfer from Parkin to its substrate. To enhance crystal production, …

… (connective tissue cells) and monocytes (white blood cells) from LRRK2-deficient pre-clinical models, we will study the … acceptor) is recylcled. Furthermore, using fibroblasts from patients with Parkinson’s disease, we will investigate … axis in neurons, such as dopaminergic neurons generated from induced pluripotent stem cells. Furthermore, if a …