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Assessing TRPML1 Agonists in GBA Parkinson’s Disease
… molecule will improve health and function in cells derived from PD patients with a GBA mutation. Study Design: We will … compounds and select the best ones to test on cells derived from human patients, to see if they improve the function and …
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Role of Neural Precursor Cells of Ventricular Wall Origin in Endogenous Plasticity in Animal Models of PD
… might be possible. However, the majority of cells generated from endogenous stem cells after damage are not new neurons, … than assumed. Possibly the regenerative potential from these precursor cell-derived glial cells is much …
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Contrasting Pathological Versus Normal Alpha-synuclein Assemblies
… normal forms of alpha-synuclein (including the tetramers) from control human brain tissue and abnormal forms from PD and DLB brain tissue. We will compare their …
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Astrocyte Activation as a Novel Marker of Disease Progression in Parkinson’s Disease: A PET Imaging Study
… yet shown movement symptoms, (ii) people with Parkinson’s from an unknown cause and (iii) control individuals at two … for disease onset and to monitor disease progression from premotor stages of Parkinson’s. Furthermore, our …
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Crohn’s and Parkinson’s Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo
March 16, 2020
… were recruited. Live human CD14+ monocytes were isolated from donors for ex vivo IFN-γ stimulation and gene … CD14+ cells in CD but not in control group. CD14+ monocytes from G2019S and R1441C LRRK2 mutated PD cases and carriers …
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Podcast: Volunteering for Parkinson’s Research: What to Know and Expect (Webinar)
April 28, 2021
… In this audio from our Third Thursdays Webinar, María L. De León, … more here . Want to see the slides and other resources from the webinar? Watch on demand . Rather listen …