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Long-term Cell Restorative Treatment for Parkinson’s Disease
… function for decades. More recently, the field has evolved from this innovative but complex fetal dopamine cell … relevant model of PD. Study Design: We will generate iPSCs from non-human primates and differentiate toward a midbrain …
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Using Mathematical Tools to Explain the Variability in Parkinson’s Disease Symptoms and Progression
… factors influencing individual Parkinson’s experience from a large pool of clinical data. Identifying these … to distill a large set of clinical measurements collected from people with PD over many years into a small number of …
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Consequences of LRRK2 Rab Phosphorylation in Neurons and Astrocytes
… have also been linked to cell death in PD. Findings from this study will help us understand how LRRK2 mutations … on Diagnosis/Treatment of Parkinson's disease: Results from this study will help us better understand how LRRK2 …
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Targeting the Mitochondrial Unfolded Protein Response in Alpha-synuclein-induced Parkinson's Disease
… or the A53T mutant and in fibroblasts (connective tissue) from those with Parkinson's disease (PD). Consistently, the … of Parkinson's disease: The findings obtained from this study will advance our understanding of the …
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N-formyl Peptides as Novel Biomarkers for Parkinson's Disease
… of these proteins, known as N-formyl peptides, can escape from the cell when mitochondria are damaged. The immune … -- and brain samples will show whether the peptides come from the site of tissue injury. We will also search for …
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Studying Changes in Phosphatidylethanolamine as a New Marker of Parkinson's Disease
… samples collected at Columbia University Medical Center from people with Parkinson's disease and from healthy people. Impact on Diagnosis/Treatment of …