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Applying Artificial Intelligence for Early Identification of Parkinson’s Disease
… classic signs of PD. Study Design: We will use EKG data from the Honolulu Asia Aging Study cohort to build AI-based … these models work on a different set of patients with PD from Methodist LeBonheur Healthcare System in Memphis, …
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PET Imaging Probe Development for Alpha-synuclein
… Next Steps for Development: The team will summarize data from this project for potential human imaging studies and … are made possible in large part through a leadership gift from Ken Griffin, Founder and CEO of the Chicago-based …
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Gene Therapy Approach to Reduce Alpha‐synuclein Aggregation in a Model of Parkinson's
… a role in reducing and clearing abnormal alpha-synuclein from brain cells. The team plans to use histological, … Parkinson's. Next Steps for Development: Positive results from this study could result in the development of clinical …
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Sleep spindles and fragmented sleep as prodromal markers in a preclinical model of LRRK2-G2019S Parkinson’s disease
May 8, 2020
… that are involved in memory consolidation. We acquired data from electrocorticography, sleep behavioral measures, and a … for underlying alterations in sleep networks resulting from the LRRK2 -G2019S mutation, and further evaluation in …
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What's in Your DNA? Understanding Parkinson's Genetics (Webinar)
May 25, 2022
… Parkinson’s disease (PD) later in life? In this audio from our Third Thursday Webinar, experts explain what … this podcast. Want to see the slides and other resources from the webinar? Watch on demand . If you have have a …
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LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease
July 19, 2022
… blood mononuclear cell (PBMCs), plasma, and fibroblasts from PD patients carrying LRRK2 G2019S mutation, (iii) … neurons, but increased in fibroblasts and PBMCs from patients, suggesting cell-type-specific effects. …