… of abnormal involuntary movements known as levodopa-induced dyskinesia (LID), which can be as debilitating as the disease itself. Dyskinesias arise when activity in a brain region called the … is disturbed by treatment with levodopa, thereby reducing dyskinesia without sacrificing the anti-parkinsonian …

… same time) or reverse (when given later) the L-DOPA-induced dyskinesia in a pre-clinical model. This is a novel insulin … is over-activated in the striatum during L-DOPA-generated dyskinesia, and that this over-activation plays a causative … L-DOPA-related medications. MSDC-0160 will be tested in dyskinesia  pre-clinical models (6-hydroxydopamine lesions …

… Rationale: Several scales are available for the rating of dyskinesia in Parkinson’s disease, and the designation of a … that best fits the needed criteria to asses all aspects of dyskinesia. Hypothesis: Given the strong clinimetric profile of the Unified Dyskinesia Rating Scale (UDysRS) and its core features of …

… efficacy and side effects (uncontrolled movements called dyskinesia) are caused by activating dopamine D1 receptors. … pathways downstream of D1 receptors for efficacy without dyskinesia. Using Sinopia’s machine learning platform, we … doses (up to 3x) of levodopa alone, with little to no dyskinesia. Hypothesis: We will assess whether the use of …

… Dyskinesia is uncontrolled, involuntary movement that may … will develop this complication, and the experience of dyskinesia varies. New and emerging treatments aim to help avoid dyskinesia. Dyskinesia Dyskinesia can involve one body part, …

… Study Rationale: Levodopa-induced dyskinesia is abnormal involuntary movements that can affect … disease after years of treatment. Available therapies for dyskinesia are only partly effective to alleviate the abnormal movements, and dyskinesia remains a hindrance to quality of life. Several …