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Biochemical Characterization of Full Length Human Recombinant LRRK1 and LRRK2
… protein by combining expertise in multiple technologies from each of our collaborating laboratories and to share our … be to genetically engineer a vector system that is derived from viruses to express the gene that we are interested in. … are several examples now of therapies that were developed from having a well characterized protein on which to base a …
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Development of an Adult Adherent Allogeneic Stem Cell Product for Treatment of Parkinson's Disease
… of this cellular product for patients who suffer from PD. Project Description : Experiments to be performed … and systemic immune modulation. Data generated from this proposal will be used as part of a pre-clinical … for use of MultiStem for treatment of patients suffering from PD in a Phase I clinical study. Relevance to Treatment …
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Biochemical characterization of full length human recombinant LRRK1 and LRRK2
… This grant builds upon the research from a prior grant: Biochemical Characterization of Full … spirit of the project that takes advantage of expertise from three laboratories, we have accomplished most of the … extremely useful for diagnosis as the signal is amplified from the top to the bottom of the cascade and, therefore, …
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Searching for Signs of Mitochondrial Breakdown in People with Parkinson’s Disease with an Unknown Cause
… nevertheless. This population is more likely to benefit from therapies targeting mitochondria. Hypothesis: We … Study Design: We will collect a small amount of blood from at least 50 people with sporadic PD, 50 healthy people … proteins. We will extract mitochondrial and nuclear DNA from a fraction of blood cells called mononuclear cells to …
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Wearable Sensors and a Web-Based Application to Monitor Patients with Parkinson's Disease in the Home Environment
… videoconferencing capability, access to data recorded from the sensors and software to analyze data recorded in … Web-based system to remotely access sensor data recorded from individuals with Parkinson’s disease in combination … via the Internet. To derive clinically relevant information from the sensor data, the research team has developed …
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In Vivo SPECT Imaging of Alpha-Synuclein Aggregation with Morphology Specific Antibody Based Ligands
… they can bind their target antigens in brain samples from pre-clinical models of PD. Relevance to … recognize their targets in samples of brain tissue taken from pre-clinical models of PD. We will test whether … various different synuclein aggregates in brain tissue from PD pre-clinical models. We further showed that the …