… This grant builds upon the research from a prior grant: From Structure to Function: Targeting LRRK2-mediated …

… This grant builds upon the research from a prior grant: Inhibition of Striatal-Enriched … model, in which there are cognitive deficits, and in tissue from those with PD. Our hypothesis is that STEP is …

… by obtaining both positive and negative travel experiences from Parkinson's patients, we will be able to identify if … symptoms within the previous two years of traveling. From this survey, we will obtain personal narratives of …

… not entirely clear how. In this study, we will use cells from people with Parkinson's to test how the LRRK2 gene … can give rise to any types of cells in the human body -- from people with PD who have Parkinson's-associated changes …

… cell death. Such toxic alpha-synuclein clumps can spread from cell to cell and multiply. It is not clear how cells … the interaction between alpha-synuclein and carbohydrates from cells. We will also identify glycoproteins that can …

… cause of this degeneration is unknown; however, recent data from animal models of PD suggest that a core structure of … fragment called NAPVSIPQ or NAP peptide protected neurons from a variety of toxic insults and improved cognitive …