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Environmental Risk Factors for Parkinson’s Disease in a Prospective Veteran Cohort
… on exposure and Parkinson’s disease also will be obtained from Veterans Administration and Department of Defense … that increase the risk of Parkinson’s and removing them from the environment. …
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Longitudinal Measurements of Glucocerebrosidase activity in Parkinson’s patients
July 30, 2020
… Methods: We measured GCase activity in dried blood spots from 1559 samples of participants in the inception PPMI cohort, collected in four annual visits (from baseline visit to Year-3). Participants (PD, n = 392; …
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Assessing Whether Cholesterol or Its Metabolites Increase the Risk of Developing Parkinson’s Disease
… metabolism and cellular defects in peripheral cells from people with PD and potential diagnostics for assessing … drugs, drugs that prevent alpha-synuclein from interacting with cholesterol or its metabolites, drugs …
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Investigating GPR55 as a Novel Neuroprotective Target in Preclinical Models of Parkinson’s Disease
… Study Rationale: Cannabinoids — substances derived from the cannabis plant — have demonstrated neuroprotective … in preclinical mouse models of PD and in postmortem samples from people with PD. Next, we will assess whether already …
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Development of PET Tracer for Imaging SV2C in Parkinson's Disease
… people with Parkinson’s disease (PD), to transmit signals from one to another. The secretion of these … and non-human primates and in postmortem brain tissue from people with PD. Impact on Diagnosis/Treatment of …
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Adaptive Immunity in the Etiology and Progression of Parkinson’s Disease
… Study Rationale: Research from our team indicates that immune cells may play central … in T cell activation in PD by examining T cells in blood from PD patients and healthy controls, and in the gut and …