… antibodies were originally produced against Abeta amyloid from Alzheimer’s disease, we found that many of them … antibody binding sites) that occur on amyloid aggregates from a number of different amyloids made from different protein sequences. For some of these …

… This grant builds upon the research from a prior grant: Comparitive gene expression analysis of … of anxiety symptoms will be selected out of the database from the previous study and included in the new scale. This … analyses of items of two existing anxiety scales from a previous MJFF sponsored study on anxiety in …

… by alpha-synuclein pre-formed fibrils. Previous work from our group has shown that gene silencing of LRRK2 is … PD. Demonstrating that LRRK2 silencing protects the brain from PD-like pathology will provide evidence in favor of … Next Steps for Development: Successful protection from pathology in pre-clinical models is necessary to …

… Accelerator Lab, and a selection of PD subject samples from Columbia University was used to assess technical and … assay. Large volume (100ccc) of whole blood was collected from 6 G2019S- healthy controls, 7 G2019S- PD, 4 G2019S+ … MLi-2, PFE-360 and GNE-7915 were determined in duplicate from each of the donor samples. The Consortium is currently …

… Disease:                      The expected results from both the in vitro and in vivo models will elucidate an … and induced pluripotent stem cell (iPSC)-derived neurons from PD patients. Remarkably, the cases displaying these … sporadic. Our study indicates that failure to remove Miro from the mitochondrial surface may constitute a common …

… study that will bring together data and samples from subjects with LRRK2 mutations with the express goal of … who will coordinate all groups having samples and data from LRRK2 mutation carriers and develop a Memorandum of … The analysis phase will involve a team of analysts from the contributing research studies implementing the …