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Identification of Small Molecule Activators of Parkin Protein
… will directly identify small molecules that turn parkin from off to on. Purified parkin protein, along with … small-molecule compounds that will protect neural cells from damage in PD by activating parkin. In this project, we … can increase the ability of parkin to protect cells from damage. Several of these compounds have been studied …
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Tobacco Mosaic Virus Antibody and Risk of Parkinson’s Disease
… Researchers will collect serum samples from four groups: 1) non-smoker PD patients, 2) smoker PD … antibodies can prevent PD by protecting mitochondria from malfunction. Relevance to Diagnosis/Treatment of … in non-smoker PD patients but not significantly different from healthy smokers. The serum anti-TMV levels of both …
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Utilization of Aptamers to Prevent Protein Aggregation in Parkinson’s Disease
… that can bind tightly to alpha-synuclein and prevent it from aggregating. We will first test aptamers for their … that can bind to alpha-synuclein in the brain and stop it from forming toxic aggregates could be an important advance. … that can bind tightly to alpha-synuclein and prevent it from clumping. We developed a novel strategy to discover …
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Drug Rescue of PINK1: New Therapeutic Modality for Treating Parkinson’s Disease
… which will focus on the drug’s ability to rescue cells from the effects of the toxin. To complete those … a drug that activates PINK1 could rescue nerve cells from the damaging effects of a toxin used to model PD. In … PD. We found that our drug protected the substantia nigra from the effects of the toxin, as significantly more …
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Michael J. Fox Foundation Awards $1.9 Million to Support Ceregene Phase Ii Gene Therapy Clinical Trial
October 10, 2006
… follows on the announcement of promising early results from Ceregene’s open-label Phase I trial of CERE-120, which … “We’re enthusiastic about the preliminary safety results from the Phase I CERE-120 trial, with no significant adverse … was made possible in its entirety by leadership support from The Pioneer Fund, a private family foundation that …
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Michael J. Fox Foundation Earmarks up to $3 Million for Clinical Research
October 3, 2005
… funding that enables researchers to translate results from the lab to clinical research,” said Deborah W. Brooks, … people living with Parkinson’s disease. Proposals may range from studies that focus on understanding Parkinson’s disease … advances for people with Parkinson’s disease.” The response from the scientific community, he adds, has been …