… interaction using human dopaminergic neurons derived from individuals with PD generated using induced pluripotent … LRRK2 models and human dopaminergic neurons derived from iPSCs to study the effect of LRRK2 mutations or LRRK2 …

… disease (PD). Failure to remove damaged mitochondria from the cell can start or speed up the course of PD. Given … the complete sets of genetic information and other data from PPMI participants to identify those who have …

… genes) to investigate SNCA methylation in 100 samples from participants with PD and 100 samples from controls. We will then perform the same analyses in …

… National Institute of Neurological Disorders and Stroke workshop in June 2014 and brings together an international group of investigators from academia, not-for-profit organizations and industry to … >3,000 individuals with PD and ~10,000 healthy participants from various sources. Hypothesis: We plan to identify novel …

… Inhibiting DLK may block this response, keep brain cells from dying, and preserve function in people with Parkinson's … will also determine if our drug can prevent brain cells from dying after exposure to toxic forms of alpha-synuclein …

… we will screen for the most suitable drug candidates from a range of molecules with demonstrated activity using … Using methods that allow us to transfer magnetization from compound to fibril, we hope to assess the distance …