-
Neuroprotective Effects of NFE2L1 in Parkinson's Models
… imply that neuron death in PD may result in part from a loss of the neuroprotective action of NFE2L1. … on the ability of NFE2L1 to reduce neurotoxicity resulting from alpha-synuclein aggregate formation or the spreading of …
-
GBA Defects Cause C5a-C5aR1-induced Neurodegeneration in Parkinson’s Disease
… molecules (e.g., glucosylceramide), preventing their cells from shedding these waste materials and functioning … dopaminergic neurons and microglia developed from blood cells or skin fibroblast of PD patients and …
-
Lentivirally-Delivered GRK2 and GRK6 for Decreasing Severity of Levodopa-induced Dyskinesia
… in Parkinson’s disease. As a result of the seed funding from MJFF, the team has now received follow-on funding from the National Institutes of Health to extendits studies …
-
Microvesicles: Biomarker and Vehicle for the Propagation of Pathological Forms of Alpha-synuclein
… to investigate whether extracellular vesicles, which derive from peripheral blood cells, can serve as disease-specific … by transporting forms of pathological alpha-synuclein from peripheral circulation to the central nervous system. …
-
Screening Assays for Restored Protein Trafficking
… is the process by which proteins are transported from where they’re made to where they’re needed inside … that restore proper trafficking, relieving neurons from this extra stress and hopefully preventing …
-
Deciphering the Genetic Architecture of the LRRK2 Gene in the Indian Population
… Parkinson’s patients and 400 matched controls ascertained from India. Using standard bioinformatic analytical tools, … catalogue of genetic variants for the LRRK2 gene for PD from the Indian subcontinent population. This cataloging of …