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Association of caffeine and related analytes with resistance to Parkinson’s disease among LRRK2 mutation carriers: a metabolomic study
August 5, 2020
… with and without the LRRK2 mutation. Methods: Plasma from 368 patients with PD and UC in the LRRK2 Cohort … 70 LRRK2 -/PD+, and 65 LRRK2- /UC, and CSF available from 68 of them, were analyzed by liquid chromatography with …
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Differentially expressed circular RNAs in peripheral blood mononuclear cells of PD patients
December 11, 2020
… analysis was then performed in blood mononuclear cells from 60 control subjects and 60 idiopathic subjects with PD. … they are highly expressed in the brain and are derived from genes with essential brain functions, they may also …
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Assessing the Effects of USP30 Inhibitors on the Removal of Damaged Mitochondria in Nerve Cells
… with relevance to PD. Combined with data derived from treatment of cells from people with PD, these studies should reveal the …
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Examining the Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein
… we will expose immune cells called microglia, isolated from the brains of mice, and with mouse forms of … labs have demonstrated the trafficking of immune cells from the circulation into the brain in PD. Understanding how …
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Resolution of Parkinson-associated Loci and Creation of Predictive Models Using Multi-omic Data Analyses
… us to understand better the genetic risk of suffering from Parkinson’s disease. However, for most of the findings … and better diagnostic for the community which can benefit from earlier treatment and better life quality. Next Steps …
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Enhancing N-glycosylation of Glucocerebrosidase and other Lysosomal Enzymes as a Disease Modifying Therapy for Parkinson’s Disease
… glycosylation is disrupted in neuronal cultures derived from PD patients, and this may disrupt the cells ability to … and mouse model. Study Design: In neuronal cultures derived from PD patients and mouse models, we will restore the sugar …