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Assessing the Effects of USP30 Inhibitors on the Removal of Damaged Mitochondria in Nerve Cells
… with relevance to PD. Combined with data derived from treatment of cells from people with PD, these studies should reveal the …
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Defining the Cellular and Molecular Determinants of Variable Genetic Penetrance in Parkinson’s Disease
… this question, or explain how certain cells in our brain go from being healthy early in life to diseased in old age. … a collection of genetically diverse stem cells derived from patients. Using advanced methods pioneered by our team, …
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Understanding Inherited and Acquired Genetic Variation in Parkinson’s Disease through Single-cell Multi-omics Analyses
… function. Around 90 regions of the DNA that we inherit from our parents show differences between people with and … in analyzing single cells to study the brain and gut from individuals who lived with and without PD. …
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LIMP-2 as a Scaffolding Protein to Characterize PD-Associated GCase Variants
… This grant builds upon the research from a prior grant: Structural Characterization of the … Therefore, we will use LIMP-2 as a tool to harvest GCase from cell culture and use different biochemical methods to …
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Identification of Novel Compounds that Improve Mitochondrial Quality Control
… improve the recognition and removal of damaged mitochondria from the cell. Hypothesis: We aim to identify novel … During the first half of the project, we will use cells from a person with Parkinson’s disease who has partial …
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Identification and Characterization of Compounds that Regulate the Activity of the LRRK2 System
… WuXi to identify compounds that bind strongly to PPM1H from its collection of 15 billion small molecules. Candidates that emerge from these analyses will then be tested robustly to verify …