… gene vector derived neurotrophic factor to be distinguished from neurotrophic factor produced normally by the host … 125I-GDNF undergoes receptor mediated retrograde transport from the striatum to the midbrain dopaminergic neuron cell bodies. To distinguish gene-derived from endogenous GDNF, we used a gene vector expressing GDNF …

… see if you can avoid general anesthesia, which puts you to sleep. Doctors can do some procedures with local or regional …

… of serotonin neurons in the induction and maintenance of dyskinesias in grafted and L-DOPA-primed animals Levodopa, … the cause of debilitating involuntary movements, so-called dyskinesias. The effects of levodopa, both positive and … The role of seratonin neurons is in the development of dyskinesias is particularly interesting since they not only …

… miRNA, DNA methylation, and histone modification data from the prefrontal cortex of 550 individuals from two prospective cohort studies of aging: the Religious … of genomic data types to look at the flow of information from DNA to protein. Specifically, we will (1) identify …

… committed $2 million to a new research intiative to study dyskinesias, the involuntary, uncontrollable movements that … associated with Parkinson’s disease. The presence of dyskinesias is a major limiting factor in achieving adequate … of patients will develop uncontrollable movements, or dyskinesias, a major of disability in their lives.  In …

… therapies. While recruitment has ended, PPMI is far from over. The study makes all its data and biospecimens  … and independent researchers will continue to gain insights from this groundbreaking study. Recent PPMI Findings A group … investigator, Dr. Kenneth Marek, published baseline data from the study in the  Annals of Clinical and Translational …