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Characterization of PP2A as a Novel Therapeutic Target and a Biomarker of PD
… Project Description : Postmortem tissue samples collected from Parkinson’s disease (PD) patients are an invaluable … and activity of protein phosphatase 2A (PP2A) in samples from a number of PD patients, compared to Alzheimer’s …
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TGF-beta Signaling as Novel Therapeutic Treatment for Parkinson's Disease
… Finding ways to protect dopaminergic neurons from degeneration could provide new therapies for … neurodegeneration and motor deficits. The results from this project will therefore enhance our understanding …
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Phase IB Follow-up Study to Assess a Second Boost Immunization With AFFITOPE® PD01A in Those Who Participated in the AFF008 Program
… This grant builds upon the research from a prior grant: Phase IB Follow-up Study to Assess Boost … analyses indicated that antibody-responders benefited from the PD01A vaccination regardless of the course of their …
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Mechanism of TFEB Dysfunction by GBA1 Mutation in Human iPSC-derived Dopaminergic Neurons
… neurons Study Design: We will use stem cells, derived from human fibroblasts (induced-pluripotent stem cells or iPSCs), to generate dopaminergic neurons from control and GBA1 mutant cells. Using molecular and …
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Role of PINK1 and Parkin in Innate Immunity: Crosstalk between Mitochondrial Dysfunction and NLRP3 Inflammasome Signaling
… clinic, key observations will be validated in macrophages from PD participants with mutations in the Parkin gene. … profiles in macrophages or monocyte-derived microglia from individuals with different familial and sporadic forms …
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The Influence of Bacterial Amyloid on Alpha-synuclein Misfolding in a Pre-clinical Model Supplement
… This grant builds upon the research from a prior grant: The Influence of Bacterial Amyloid on … We will carry out further studies on the material obtained from the investigations supported by the original project. …