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Disruption of Pathological Protein-protein Interactions in Alpha-synuclein
… of alpha-synuclein. Next Steps for Development: Future work from this study will involve screening larger, more diverse libraries. From there, we will move to testing compounds in …
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LRRK2 Kinase Activity and Mitochondrial DNA Damage in Parkinson's Disease
… LRRK2 kinase activity. We have found that white blood cells from those with LRRK2-related PD have damage to their … inhibit LRRK2 can fix mtDNA damage in white blood cells from individuals with LRRK2-related PD. We will then test, …
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Studying Age-related Chronic Inflammation in Parkinson's Disease
… Design: In this study, we will use existing blood samples from people with PD and from healthy people who are 100 and older. To accomplish the …
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Studying Structures of LRRK2 to Understand and Slow Parkinson's Disease
… This grant builds upon the research from a prior grant: Structure Window into LRRK2: Kinase or … the detailed structure of a pure protein extracted from the cell. To study LRRK2 inside the cell, we use …
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Analyzing Parkinson’s Data with the Razor Platform for Hypothesis Generation and Scientific Decision-making
… Study Rationale: Experts from various biomedical fields are trying to identify … can read and comprehend millions of scientific documents from hundreds of key knowledge domains -- such as …
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Small-molecule Inhibitor to Stop Alpha-synuclein Spread for the Treatment of Parkinson's Disease
… associated with Parkinson's) aggregates (clumps) move from neuron-to-neuron is gaining widespread acceptance as a … of our small molecule. We are confident that results from these distinct but complementary approaches will help …