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Studying Measures of LRRK2 Activation and Lysosomal Dysfunction in Parkinson's Disease
… Study Design: We will collect urine and blood samples from 40 donors. Within 24 hours of blood collection, three … and peripheral blood mononuclear cells) will be collected from the blood samples. A small fraction of each cell type …
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Measuring Metabolism of Alpha-synuclein in Extracellular Fluids
… acid into the protein. Alpha-synuclein needs to be isolated from all the other proteins present in biological fluids and … on tissue culture cells as well as cerebrospinal fluid from healthy human volunteers. The only way to detect the …
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Generation of a dorsal motor nucleus X (DMX) specific pre-clinical model of alpha synuclein overexpression to study the etiology of autonomic dysfunction in PD
… aggregates in DMX. Furthermore, since vagal nerves from the DMX control gastrointestinal (GI) function, we will … by prominent motor impairment, patients often suffer from non-motor symptoms such as autonomic dysfunction (i.e. …
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Are Anti-Parkinsonian Treatments Disease Modifying?
… Response Scale (UPDRS) in the ELLDOPA and TEMPO trials from the Parkinson’s Study Group will be analyzed in each … Anticipated Outcome: We expect to confirm the predictions from DATATOP that both levodopa and rasagiline have disease …
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Preventing falls and improving mobility in people with Parkinson's disease
… to increase, by lessening the burden of care arising from the disease. The results will provide information about … in people with PD who live at home. 201 people with PD from Melbourne, Australia have participated in 8 week …
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Improving the Long-term Survival & Functionality of the Transplanted Human Dopaminergic Neurons Through Space Creation Strategy
… This grant builds upon the research from a prior grant: Improving the Long-term Survival & … be inserted into the host model. The cells are sheltered from initial host responses, which eventually diminish. The …