-
Neuregulin-2â: A Novel Trophic Factor for Midbrain Dopamine Neurons
… great importance. This project will evaluate two proteins from the neuregulin family of growth factors as novel … Recent evidence, however, suggests that a protein derived from the neuregulin-2 gene, called NRG-2beta, may be a more …
-
The Transfer of Alpha-Synuclein: Mechanistic and Therapeutic Studies
… the researchers’ collective expertise to screen MAbs from one of the largest anti-alpha-synuclein MAb libraries. … advance of immune therapy for Alzheimer’s disease (AD) from pre-clinical studies to clinical trials in AD patients, …
-
LRRK2 Target Engagement Ligand (Supplement)
… This grant builds upon the research from a prior grant: LRRK2 Target Engagement Ligand Promising Outcomes of Original Grant: New compounds from several distinct series have been synthesized that have …
-
LRRK2-associated Mitochondrial DNA Damage as a Phenotype for Unbiased Screening
… that neurons derived via induced pluripotent stem cells from LRRK2 PD patients have damage to their mitochondrial … (skin cells) or lymphoblasts (white blood cells) from people with LRRK2 mutations show the mtDNA damage …
-
Motor Proteins as Novel Drug Targets of Disease-modifying Treatments for Parkinson’s Disease
… novel therapies for PD. Anticipated Outcome: The outcomes from this research will establish whether molecular motors … important for clearing damaged mitochondria, especially from brain cells. This will open up new areas of research …
-
Mirtazapine as a Treatment for Pathological Gambling
… gambling, are often taken off this drug and cannot benefit from its therapeutic effects. This study may show that … mirtazapine in these patients can allow them to benefit from movement enhancing effects of pramipexole without the …