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Gremlin-1, a Putative VTA-derived Neuroprotective Factor in Parkinson's Disease
… that certain brain neurons which are normally protected from Parkinson’s disease (PD) contain high levels of the … neuroprotective factor has been genetically deleted from those brain cells. With this model, it will be possible …
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The Sigma 1 Receptor as a Target for Disease-modifying Therapies in Parkinson's Disease
… improve more than one mechanism. Based on a vast literature from other disease models, we hypothesize that Sig-1R … treatment regimen that will protect nigral dopamine neurons from 6-OHDA-induced cell death, and/or promote axonal …
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Evaluation of a Viral Non-coding RNA as a Neuroprotective and Neurorestorative Therapy in Chronic Models of Parkinson's Disease
… This grant builds upon the research from a prior grant: Evaluation of a Novel Non-coding Viral … have already identified clearly protects neurons in the SN from cell death when we deliver the RNA prior to a rapid and …
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Serum Biomarkers for Parkinson's Disease
… will attempt to repeat this finding using blood samples from 50 PD patients, 50 normal control subjects, and from 50 AD patients to determine whether our preliminary …
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The Role of LRRK2 in Regulating a Calcium-Dependent Pathway Involving Lysosomal Stores and NAADP
… LRRK2 regulates acidic calcium stores in human fibroblasts from control and mutant LRRK2 patients. We will also … strategies targeting downstream events of LRRK2, distinct from a classical kinase inhibitor approach. Anticipated …
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Analysis of LRRK2 Antibodies
… their use in techniques frequently used to measure LRRK2 from different sources. Because much research is being … This will help firmer conclusions to be undertaken from research undertaken. This study is a part of MJFF’s …