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QE3 Trial Ancillary Biomarkers Study
… of PD. The ancillary study involves obtaining blood samples from a subset of patients participating in the trial and … Outcome: We expect to have processed blood specimens from 150 QE3 subjects and 50 normal controls that are stored …
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Neuroprotective effects of isradipine in a pre-clinical model of Parkinson’s disease
… will utilize electrophysiological methods in tissue slices from treated mice. Second, we will determine whether low doses of isradipine protect dopaminergic neurons from intrastriatal injection of a dopamine cell toxin – …
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Isoforms of Alpha-synuclein as Biomarkers for Diagnosis and Progression of Parkinson's Disease
… splicing variants/isoforms in CSF were different from those in plasma. Thus, the goal of this study is 1) to … First, various isoforms of alpha-synuclein will be purified from CSF and plasma, followed by the characterization of the …
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Testing of small molecules in an alpha-synuclein pre-clinical model of Parkinson’s disease
… molecules (tocainide, FTI-277 and (+)-UH 232) identified from a genetic high-throughput screening performed on … the journal Human Molecular Genetics and follow-on funding from the Swiss National Science Foundation. …
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T Cell Mediated Neuroprotection by Therapeutic Vaccination for Parkinson's Disease
… response. We previously demonstrated that immune cells from donors immunized with glatiramer acetate, a peptide … attenuating MPTP-induced neuroinflammation and protecting from subsequent neurodegeneration. Anti-CD3 activated …
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Longitudinal changes in patterns of motor UPDRS subscore
… (1) whether age of onset distinguishes “slow progressors” from more rapid progressors, (2) whether individuals with … gait symptoms progress at a different speed from those with less prominent tremor, and (3) whether …