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Responsive, Closed-Loop Approach to Treat Freezing of Gait in Parkinson’s Disease
… in people with Parkinson’s disease (PD). Recent findings from deep brain stimulation (DBS) trials have been promising … deployable solution for freezing of gait, and results from this project can possibly be moved into a larger …
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Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
… take place in brain cells to assure proper quality control, from the identification of the defective component to their … outside cells with findings in intact brain cells obtained from different pre-clinical models of PD. This back and …
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Pum2-mediated Translational Regulation of Alpha-synuclein mRNA Associated with Mitochondria
… (ROS) made by mitochondria induce new protein synthesis from the alpha-synuclein mRNA pool associated with … ROS cause new alpha-synuclein protein synthesis from mitochondria-associated mRNA and this new population of …
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LRRK2 Effects on Neural Differentiation (Supplement 2)
… This grant builds upon the research from a prior grant: LRRK2 Effects on Neural Differentiation … the function of LRRK2 is poorly understood. Previous data from this group shows that LRRK2 regulates synapse …
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Analysis of Brain and Peripheral Small Molecule Levels in Parkinson’s Disease
… of approximately 65 different chemicals in CSF and blood from both Parkinson’s disease patients and control … be to run a second, blinded study where PD patient samples from another cohort are compared to healthy controls to …
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Michael J. Fox Bio Keynote to Urge Bolder Moves in Translational Research
May 3, 2007
… advocate Michael J. Fox will address thousands of leaders from the biotech and pharmaceutical industry at the BIO … greatest potential to hasten new therapeutics on their path from labs to patients. This funding strategy alters the risk …