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Epigenetics of Parkinson’s Disease in Japanese Males in the Kuakini Honolulu Heart Program
… will be reflected in the subjects’ DNA isolated from blood collected at midlife prior to autopsy. … markers of PD or organochlorine/plantation work exposures from the brain tissue and blood will be categorized into … a study to validate these findings in a larger sample from an at-risk population of past plantation workers, and …
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Identifying and Characterizing Genetic Causes of REM Sleep Behavior Disorder and Parkinson’s Disease
… the RBD-PD axis. Next Steps for Development: The results from this project should be replicated in more cohorts with … (RBD), we expended the panel of genes that we studied from 40 to 51. In addition, we conducted a study of genetic … genetic variants that are associated with conversion from RBD to PD. Such genetic variants have the potential to …
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Role of Nicotinamide N-methyltransferase in Genetic Models of Parkinson’s Disease
… and progression of the disease. This idea arises from data showing that NNMT expression is significantly … that act as neurotoxins could be avoided or even banned from usage in agriculture, helping to create a healthier … it the ability to save dopamine-producing brain cells from death. The same holds true when NNMT production in …
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LEAPS Project to Advance Encapsulated Cell Delivery of GDNF
July 1, 2004
… met. This project was made possible through a lead gift from Anne and Bernard Spitzer with matching funds provided … the encapsulated cell technology (ECT) delivery of GDNF from a theoretical concept to a therapeutic reality. GDNF, … as in early clinical trials. Recently, preliminary results from a phase II trial employing another delivery system …
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Michael J. Fox Foundation Announces Support for LRRK2 Cohort Studies in Ashkenazi Jews and North-African Arab-Berbers
October 14, 2009
… therapeutics targeting LRRK2. A team of investigators from the Mayo Clinic, Jacksonville, and the Institute of … will collect clinical, genetic and olfactory information from nearly 4,000 individuals with LRRK2 mutations, … as well as other selected speakers, is available at www.pdonlineresearch.org/meetings . …
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The Michael J. Fox Foundation Commits Up to $5.75 Million in Funding For 2010 Critical Challenges in Parkinson's Disease
March 2, 2010
… develop drug-activity biomarkers that can improve outcomes from future clinical trials of treatments targeting the … pipeline in order to lay the groundwork for clear outcomes from future clinical trials testing LRRK2-associated drug … should propose drug development projects that can benefit from access to APDC’s exceptional bank of well-characterized …