… disease, so this idea is exciting. However our data comes from cell lines, and not all observations from cell lines hold true for humans and pre-clinical …

… We will construct the full complexity model for LRRK2 from structural analysis of the component parts using related domains from other organism. This should be crucial for identifying …

… mutations in the kinase domain (G2019S). Fibroblast lines from age- and gender matched healthy subjects will be reprogrammed as controls. From each individual’s fibroblast line, 2-3 fully …

… factor in the disease. Two significant outcomes may result from the proposed research.  First, a diagnostic tool, … and with that, a way to design ways to prevent neurons from dying.  Proteases are excellent drug targets and …

… fumaric acid ester therapies is that patients can suffer from gastrointestinal (GI) adverse events.  XenoPort is … able to identify which patients would most likely benefit from such a treatment.   Anticipated Outcome: If this …

… with Parkinson’s disease (PD) meets diagnostic criteria for dementia, the brain has already been ravaged. … fluid, clinical quantitative analysis of motor control and comprehensive memory testing to fully characterize the … are fully manifest. In addition, some PD patients with concomitant Alzheimer’s disease pathology might benefit from …