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Identification of the LRRK2 Phosphatase
… such on-off switch involving adding and removing phosphates from LRRK2. LRRK2 cellular phosphosites are dynamically … the dephosphorylation of LRRK2 cellular phosphosites. Hits from the screening will be extensively tested in vitro and …
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Pre-clinical Development of the Oligomer Modulator anle138b and Establishment of a Novel Seeding-based Biomarker
… This grant builds upon the research from a prior grant: Evaluation of the Oligomer Modulator … models. Data about the minimal effective dose from these studies combined with the results of the toxicity …
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Cell-Permeable Parkin Protein Suppresses Parkinson's Disease-associated Symptoms
… of cell-permeable recombinant Parkin protein, the results from this study may demonstrate that iCP-Parkin alters the … with the US Food and Drug Administration. Outcomes from this series of studies will provide the foundation for …
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Alpha-synuclein-induced Astroglial Inflammation as a Trigger of Parkinson's Disease
… cells that can become different types of cells) generated from individuals with familial and idiopathic PD into … time. We tested our hypothesis using astrocytes created from stem cells donated by healthy people and by people with …
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Total and Proteinase K-resistant Alpha-synuclein in BioFIND Samples
… will be determined in blood samples obtained from the BioFIND clinical study, including samples from healthy participants and those with moderate and severe …
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Characterizing Transgenic Pre-Clinical Models that Express a Mutant LRRK2 Gene Selectively in Adulthood
… to Diagnosis/Treatment of Parkinson’s Disease: The results from this in vivo study will advance our understanding of PD … known genetic causes, but sporadic PD cases might suffer from epigenetic modification to PD genes such as LRRK2 later …