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Validation of a Novel Pre-Clinical Model of Dyskinesia in PD
… This grant builds upon the research from a prior grant: Targeting Beta-arrestin Signaling in the … Investigation: Our compelling results from the target validation grant showed that we could …
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Effect of Tyrosine on Orthostatic Hypotension in Parkinson’s Disease
… Individuals with Parkinson’s disease (PD) commonly suffer from orthostatic hypotension and low BP due to reduced … improvement in blood pressure in people with PD that suffer from orthostatic hypotension. Presentations & Publications …
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Dynamics of Alpha-synuclein Aggregation in Dopamine Neuron Degeneration and Recovery
… This grant builds upon the research from a prior grant: Reversing Pre-existing Pathologies of … We believe that our research tools and findings resulting from these studies will greatly accelerate the search for a …
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Diurnal Fluctuations in Secreted Inflammatory Factors
… peripheral and central inflammation that might benefit from anti-inflammatory regimens to slow down progression of … patients with XPro1595 who are likely to benefit the most from reducing inflammation. Because XPro1595 is an …
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Targeting the Voltage-Gated Proton Channel Hv1 for Neuroprotection
… pre-clinical models lacking Hv1 were found to be protected from neuroinflammation and cell death in a stroke model. In … will determine whether models lacking Hv1 are protected from the dopaminergic neurotoxicity of PD. Relevance to …
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Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking 2013
… This grant builds upon the research from a prior grant: Impact of LRRK2 Kinase Activity on … of neurotransmitters). A previous MJFF-funded project from this group showed that LRRK2 kinase activity is also …