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Non-kinase Targets in LRRK2 Biology
… mice carry a 2385R mutation, we see the effects we predict from our biochemical assays. In the long term, we think this … explored. Anticipated Outcome: The first outcome from these experiments will be to understand how G2385R risk …
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Neuromelanin in Circulating Phagocytes May Reveal Early Neurodegeneration in Parkinson’s Disease
… test for neuromelanin using pigmented epithelial cells from the retina of the eye (which is actually a part of the … Now we can do a pilot experiment with white blood cells from newly diagnosed PD subjects to show whether or not we …
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Mechanisms of Cellular Regulation and Post-translational Modification of LRRK2
… This grant builds upon the research from a prior grant: Regulation of LRRK2 Membrane Association … and extended the lifetime of the protein by protecting it from proteolytic degradation. In the course of these studies …
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Parc (a Parkin-related E3 Ligase): Functions in Neuronal Survival and Parkinson’s Disease
… is important for eliminating any damaged mitochondria from neurons -- a phenomenon that is being extensively … for removal the cytochrome c protein, which is released from damaged mitochondria and has the potential to kill …
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Identification of De-ubiquitinating Enzymes for Parkin-mediated Mitophagy
… disease through the inability to clear damaged mitochondria from neurons. In this project researchers aim to identify … order to restore parkin activity to normal levels in cells from Parkinson's disease patients. March 2015 …
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Bach1 and Bach2 Inhibit Nrf2 Antioxidant Responses in Substantia Nigra Neurons
… and the reduction of oxidative stress that would result from inhibition of Bach1 or Bach2. Relevance to … into increased antioxidant levels and protect brain cells from damage. We have measured the function of …