… of Kv7 channels and the pathophysiology of levodopa-induced dyskinesias, openers of these channels may provide novel therapeutic approaches for levodopa-induced dyskinesias. Project Description: Our first experiments with … doses in a pre-clinical model of levodopa-induced dyskinesias. However, it is necessary to examine the …

… Serotonin Transporters for the Treatment of L-DOPA-induced Dyskinesia Promising Outcomes of Original Grant: Initial … transporter (SERT) for the treatment of levodopa-induced dyskinesia (LID) revealed, as hypothesized, that blocking … Dyskinesia …

… Levodopa-induced dyskinesia in Parkinson’s disease is thought to depend on an … model of Parkinson’s disease and levodopa-induced dyskinesia. Tests of physiological motor performance and … Dyskinesia …

… the body. To date, there is no effective medical treatment for levodopa-induced dyskinesia other than surgical … The objective of this proposal is to develop new compounds and to test them in pre-clinical models of … objective is to further develop these glycosylated peptide compounds and to test them for their ability to penetrate …

… the replacement cells developed debilitating 'off-medicine' dyskinesias. Dyskinesias are unwanted, excessive, involuntary movements. … of investigators has noted that the emergence of these dyskinesias seems to appear after the patients are withdrawn …

… however long-term use leads to disabling levodopa-induced dyskinesia (LID) in the vast majority of patients. NMDA … will be studied in a pre-clinical model of levodopa-induced dyskinesia. A xenon/oxygen mixture will be administered to … or avoiding treatment-induced complications such as dyskinesia, which affects the long term efficacy of the …