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Salivary Biomarkers for Parkinson's Disease
… and DJ-1 in saliva, a body fluid that is quite different from human CSF. The other major goal is to investigate major … levels of α-synuclein and DJ-1 in 200 saliva samples from a control cohort (subjects are in their 20s-80s with an …
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Making a List to Prepare for Your Doctor Appointment
April 26, 2019
… How much information should you include? Jim Force, 71, from Alta Loma, California was diagnosed with Parkinson's … periods are more definitive now. It can be hard to get up from a chair or sofa or to walk any distance. Had first …
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Isotopic Stabilization of Dietary Polyunsaturated Fatty Acids as a New Treatment Paradigm for Parkinson's Disease: MPTP and Paraquat Pre-clinical Model Feasibility Studies
… of Parkinson’s disease (PD). Essential (available from diet only) polyunsaturated fatty acids (PUFAs) are one … of PUFAs ensures they are distributed throughout the body from diet. Project Description : Well-established MPTP and …
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Inflammatory Stimuli as 'Second-Hit' Triggers for Development of Progressive Nigral Degeneration
… a significant fraction of nigral dopaminergic neurons from death. In addition to developing new chronic … for developing PD. Because post-mortem analyses of brains from individuals bearing DJ-1 mutations have not been …
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The role of serotonin neurons in the induction and maintenance of dyskinesias in grafted and L-DOPA-primed animals
… PD, but the extent of seratonin neuron degeneration varies from patient to patient. The role of seratonin neurons is in … innervation in the synthesis and release of dopamine from systemically administered levodopa and in the …
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Effect of the Stimulation Frequency of STN DBS on Swallowing Function in Patients with Parkinson’s Disease
… We anticipate that the benefit of the swallowing function from 60 Hz low frequency stimulation persists in the … freezing of gait. The benefit of the swallowing function from 60Hz low frequency stimulation persists in the six-week …