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Utility of a Novel Nicotinic Receptor Agonist for Treating Levodopa-induced Dyskinesia
… demonstrates efficacy in these studies we will use the data from the study to support further testing in Parkinson’s … benefit for Parkinson’s disease patients suffering from troublesome dyskinesia. …
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Effect of Alpha-Synuclein Depletion in Dopamine Neurons of Pre-Clinical Models
… in the brain of Parkinson’s disease patients would benefit from using a pre-clinical model in which the alpha-synuclein … new model, we have encountered certain problems aroused from the side effect of our manipulations on the …
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Optimizing Metalloporphryins for Clinical Development Supplement 2
… This grant builds upon the research from a prior grant: Optimizing Metalloporphryins for … shown high potencies as antioxidants. A recent NADD award from the MJFF enabled optimization of the structures of …
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Assessing Glucocerebrosidase in Sporadic Parkinson’s Disease
… therapies for PD. Project Description: Brains from sporadic PD patients without GBA gene mutations will be … activity and protein levels in multiple brain regions from sporadic PD compared to controls. GBA mutation carriers …
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Novel Quantification Paradigm in Parkinson’s Disease Neurochemical Imaging
… Project Description: Scientists will analyze DAT scans from the Parkinson’s Progression Markers Initiative (PPMI) … of such techniques. Furthermore, data obtained from the various analysis methods will be combined using …
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Rating Segmental Progression of Cardinal Motor Symptoms in Early Parkinson's Disease
… Project Description: This study uses data available from participants in the MJFF-sponsored Parkinson’s … Rigidity Segmental Score and the Combined Segmental Score from MDS-UPDRS-III of PD patients enrolled in the PPMI study …