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AAV-Based Approach for Regulatable and Cell Type-Specific Gene Therapy in PD: Restoring Excitability to an Intrinsically Silenced Subpopulation of GP Neurons
… therapy in PD patients. This work led to additional support from MJFF to continue these studies. …
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Maintenance of Nerve Terminals by Local Synthesis of Proteins in Axons
… processes that connect neurons extend for long distances from the neuronal cell body. Over the past few years it has …
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Targeting the Stress Sensor PERK for the Treatment of Parkinson´s Disease
… is characterized by impairment of motor control as a result from extensive neuron death. The primary mechanism …
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Exploration of Relationships and Formulations of Molecular Tweezers
… through the blood-brain barrier and possibly its conversion from an injection to a pill. Impact on Diagnosis/Treatment …
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Melanoma-related Gene as a Therapeutic Target for Parkinson's Disease
… treatments for PD. Anticipated Outcome: The insights gained from this project will shed light on a virtually unexplored …
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Contribution of the Unfolded Protein Response to Idiopathic and LRRK2-driven Parkinson’s Disease
… stain autopsy brain tissue for markers of UPR activation from people with and without PD as well pre-clinical models …