… in the clinic. Anticipated Outcome:           Results from these two timing paradigms (pre- and post- … it reduces existing alpha-synuclein pathology. Results from this study suggest NOR does not necessarily clear …

… This grant builds upon the research from a prior grant: The Unfolded Protein Response (UPR) … glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) …

… This grant builds upon the research from a prior grant: CD163+ Macrophages as Tools for … models of PD. Furthermore, analysis of blood samples from people with PD supports the involvement of the …

… cognitive and neuropsychiatric disturbances; ii) conversion from PD without cognitive disturbances to PD with mild … or with dementia, as well as; iii) the slope of decline. From post-mortem brain tissue will also include a study of …

… strategy. Project Description: Blood will be drawn from Parkinson’s disease patients and one blood cell type … those patients who are likely to respond to our drug from those who are unlikely to respond.  We have developed a …

… scales that maximally separate placebo-associated changes from amantadine-associated changes. The results will … dose and therefore settle for a sub-optimal benefit from the best medical therapy available for their disease.” …