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VEGF-B - A New Neurotrophic Factor for Treatment for Parkinson's Disease
… effect by VEGF-B that was statistically not different from the effect of GDNF. We will further test if VEGF-B is … for publication, in press, or published) that resulted from the work made possible by this award. Abstracts …
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Selective Inhibition of Cyclic Nucleotide Phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease
… This grant builds upon the research from a prior grant: Selective Inhibition of Cyclic … used to test drug candidates. The usual progression from pre-clinical models to patient assumes that all respond …
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Regulated rAAV-GDNF to treat Parkinson's disease: Translational research plan
… This grant builds upon the research from a prior grant: rAAV-ribozyme Mediated Parkin Knockdown … of the disease, therefore end stage patients don’t benefit from GDNF. In order to make GDNF gene therapy safer, we …
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Ghrelin - a Peripheral, Preclinical Biomarker for Parkinson's Disease
… This grant builds upon the research from a prior grant: Multimodal assessment of gastric … For both conditions, ghrelin serum concentrations different from healthy controls have been described. However, it is …
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Characterization of PARK16
… PARK16 in Parkinson’s disease patients of Chinese ethnicity from Taiwan. Initial studies will be performed in … will be further analyzed in Parkinson’s disease patients from North America, Europe and North Africa. As well as the …
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Upregulation of MsrA: A Neuroprotective Strategy for the Treatment of Parkinson's Disease
… protein aggregation mediated toxicity. The results from the second experiment have not been conclusive as the … readout of MsrA activity in the brain that can be measured from tissue samples. We are currently investigating methods …