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Investigating Defects in Mitochondrial Functions, Transport, Fusion/Fission in LRRK2 Pre-clinical Models
… This grant builds upon the research from a prior grant: Park8 Pre-clinical Models and LRRK2 …
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Novel protocols for the differentiation and functional integration of embryonic and neural stem cell-derived dopaminergic neurons in rodent models ofParkinson’s Disease
… and technology to: (1) Generate dopaminergic neurons from human embryonic and/or neural stem cells. (2) Examine …
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Prion-like Dissemination of Synuclein Pathology: A Non-human Study
… in pre-clinical models, we will first extract Lewy bodies from post-mortem PD brains. Once those have been …
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Collaborative Validation of Oxidized DJ-1 Antibodies For PD Biomarker Study
… This grant builds upon the research from a prior grant: Oxidized DJ-1 as a Biomarker for …
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Gene Expression Changes in Striatal Cholinergic Interneurons Associated with Levodopa-induced Dyskinesia
… — which release the neurotransmitter acetylcholine — from part of the brain called the striatum in …
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GluN2D Antagonism in the Subthalamic Nucleus for the Treatment of Parkinsonism
… This grant builds upon the research from a prior grant: Use of NR2D-selective NMDA Receptor …