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Clinicopathological Features of LRRK2-related Parkinson's Disease
… Hypothesis: We propose that pathological features distinct from Lewy bodies are important contributors to the clinical …
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Investigating Alpha-synuclein Clumping in the Organoid Model of Parkinson's Disease
… brain cells. These cells will be generated from induced pluripotent stem cells -- cells that can give …
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Evaluation and Comparison of Existing Tests for Alpha-synuclein
… predict the onset or progression of PD or differentiate PD from other diseases related to alpha-synuclein. This is, in …
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The Effect of Psychological Stress on the Symptoms of Parkinson's Disease
… Study Design: In this study we will analyze data of people from the Fox Insight cohort (approximately 1,000 people with …
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Extracellular Vesicles Produced by Microglia as Novel Biomarkers of Parkinson's Disease
… using a new method that we helped to develop. Using results from that study, we will next seek EVs produced by microglia …
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Studying the Function of Modified Alpha-synuclein in Health and Disease
… Study Design: We aim to collect modified alpha-synuclein from healthy brains using a novel technique and identify …