… Study Rationale: Although the cause of levodopa-induced dyskinesia is still unclear, these motor complications … signaling in brain areas involved in levodopa-induced dyskinesia. Interestingly, the 5-alpha reductase inhibitor … of 5-alpha reductase by finasteride is able to counteract dyskinesia in a pre-clinical model of Parkinson’s disease. …

… Efficacy of ADX48621 in the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease Study Rationale:           … in particular, has shown significant effects in reducing dyskinesia in a pre-clinical model of Parkinson’s disease levodopa-induced dyskinesia (PD-LID). This study will determine what dose of …

… issues for prevention and management is drug-induced dyskinesia. Dyskinesias are abnormal and involuntary movements that … on understanding the regions of the brain responsible for dyskinesias and the brain chemicals involved. As a result, …

… loss of anti-parkinsonian effect and a lower degree of dyskinesias. Anticipated Outcome: The synthesis of a major … on activity and a higher dose and/or a later time to induce dyskinesia in comparison to regular levodopa. Final Outcome … disability reduction and the immediate induction of dyskinesia. Furthermore, a significant prolongation of the …

… :  The choreic and dystonic movements, or dyskinesia, which develop in response to prolonged treatment … for PD. Using a pre-clinical model of levodopa-induced dyskinesia (LID), we found that this condition is associated … of the brain where mTORC1 is abnormally activated during dyskinesia. This approach will reduce possible side effects …

… Study Rationale:                    Levodopa-induced dyskinesia is a major dose-limiting effect associated with … preventing the development or reversing levodopa-induced dyskinesia in PD. To this end, the objective of this project … dopamine 4 (D4) receptor antagonists for the treatment of dyskinesia. The study of D4 has been relatively neglected …