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Role of mGluR4 in the Modulation of Levodopa-induced Motor Performance and Dyskinesia
… Objective/Rationale : Dyskinesias are uncontrollable involuntary body movements … combination with L-DOPA on the induction of L-DOPA related dyskinesias in a well known pre-clinical model of PD. …
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Targeting of 5-HT1A and 5-HT2A Receptors Against Levodopa-induced Dyskinesia
… is beset by abnormal involuntary movements, also known as dyskinesias. Research evidence indicates that aberrant …
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Caffeine and the Risks of Disease Progression and Dyskinesias in PD
… to repeated L-dopa treatment in an animal model of the dyskinesias, which are a major complication of L-dopa …
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Nicotinic receptor agonists and L-dopa-induced dyskinesias
… with the development of abnormal involuntary movements or dyskinesias that may be as debilitating as the disease … of therapeutic value for the treatment of levodopa-induced dyskinesias in Parkinson's disease. Project Description: …
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5-alpha-reductase Inhibition for the Treatment of Levodopa-induced Dyskinesia
… Study Rationale: Although the cause of levodopa-induced dyskinesia is still unclear, these motor complications … signaling in brain areas involved in levodopa-induced dyskinesia. Interestingly, the 5-alpha reductase inhibitor …
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Metabotropic glutamate receptors in L-DOPA-induced dyskinesia
… Levodopa-induced dyskinesia in Parkinson’s disease is thought to depend on an … model of Parkinson’s disease and levodopa-induced dyskinesia. Tests of physiological motor performance and …