… such as the striatum. Oxytocin may reverse levodopa-induced dyskinesias by reducing the activity of a subset of neurons … oxytocin to show which may have beneficial effects against dyskinesias in a pre-clinical model. Project Description: … and then treat then with levodopa, which causes measurable dyskinesias. Researchers will treat these models with …

… Objective/Rationale:              Dyskinesia (involuntary fractured, jerky movements) is a … movement) can decrease the expression of levodopa-induced dyskinesia in pre-clinical models. This study will … are also effective in preventing the development of dyskinesia, when given along with levodopa in pre-clinical …

… with serious motor complications called levodopa-induced dyskinesia (LID). Once established, LID is very hard to … 50 PD patients without LID. The severity of disease and dyskinesia will be scored using the Unified Parkinson’s Disease Rating Scale and the Unified Dyskinesia Rating Scale. We will collect blood and CSF at a …

… Objective/Rationale:              Levodopa-induced dyskinesias are abnormal involuntary movements that may … nicotine can modify striatal dopaminergic activity and ease dyskinesia. Of relevance, nicotine might best improve dyskinesia if striatal dopaminergic transmission is …

… eventually result in the development of levodopa-induced dyskinesia in most Parkinson’s disease (PD) patients. But … acetylation, moderates the severity of levodopa-induced dyskinesia in PD patients without altering parkinsonian … are the most relevant to interfere with the development of dyskinesia, we will use preclinical models and carry out a …

… Long-term treatment for Parkinson’s with levodopa can cause dyskinesia or involuntary movements. Other drugs like … of specific gene variations could predict the appearance of dyskinesia. Study Design: We will use DNA extracted from the … which gene variant combination is shared by PD who develop dyskinesia. We will also check whether there is any …