NIC-PD Trial to Assess the Disease-modifying Potential of Transdermal Nicotine in Early Parkinson's Disease
Clinical Intervention Awards, 2009
No drugs are available that can slow or stop the progression of Parkinsonís disease (PD). Nicotine is a promising substance for this purpose. Firstly, epidemiological studies suggest a protective effect of nicotine: PD is much less prevalent among smokers compared to never-smokers. Secondly, in experimental neuroscience, including in pre-clinical models, nicotine has shown beneficial effects. Thirdly, the drug is widely available and exhibits a favorable safety profile.
The NIC-PD trial assesses for the first time the disease-modifying potential of transdermal nicotine (nicotine patches) in patients at very early stages of Parkinsonís disease who do not yet require symptomatic treatment. About 150 PD patients will be enrolled in this multi-center trial. These patients will be randomly assigned to receive either nicotine patches or placebo patches over a treatment period of 12 months in a double-blinded manner. Double-blinded means that neither the patient nor the treating physician know whether the patient receives placebo or the active drug (nicotine). The effect of nicotine will be assessed by standardized clinical rating scales (UPDRS). If required by the patient, symptomatic therapy is allowed.
Relevance to Diagnosis/Treatment of Parkinsonís Disease:†
The disease-modifying potential of nicotine is of great value, as this approach could easily be translated in routine care due to the wide availability and safety of the investigated substance.
This study will show whether nicotine can slow disease progression in Parkinsonís disease. If effective, nicotine could serve as a model substance for disease modification in other neurodegenerative disorders. Also of note,†NIC-PD is the first investigator-initiated, transatlantic collaboration between PD networks in Germany and the United States.
INTERIM PROGRESS REPORT
Results are expected in early 2017.
- NIC-PD Launches
- Podcast: Could a Nicotine Patch Slow the Progression of Parkinsonís Disease?
- Study Reports Nicotine Patch Slows Memory Loss
Hertie-Senior-Research Professor at Philips University of Marburg
Location: Barcelona, Spain
Professor of Neurology and Community and Preventitive Medicine at University of Rochester Medical Center
Location: Rochester, New York
Senior Physician at Saarland University, Department of Neurology
Location: Homburg/Saar, Germany