HOME ›   OUR ROLE & IMPACT ›  FoxFeed Blog

FoxFeed Blog

Podcast: Inosine May Hold Potential for Parkinsonís Disease, but Patients Urged to Act with Caution

Posted by  Maggie McGuire, December 23, 2013

Subscribe on iTunes RSS Feed Download Audio File

Today the Parkinson Study Group published in JAMA Neurology that with medical supervision, it is possible to safely raise levels of the antioxidant urate by taking the urate precursor inosine. Previous research showed that higher urate levels were associated with lower risk and slower progression of Parkinsonís disease.

One quick, very important note: Inosine is available commercially as a dietary supplement, but patients should act with caution. Inosine has not been proven as a therapy for Parkinsonís, and in the absence of medical supervision, it can cause serious side effects such as gout, kidney stones and possibly high blood pressure. As with all early-stage research, itís critical to discuss any medications or natural supplements with your physician before taking them.

The Michael J. Fox Foundation invested more than $5 million in this study, Safety of Urate Elevation in Parkinson's Disease (SURE-PD). Inosine could become a disease-modifying treatment for Parkinson's disease, used to prevent or slow the disease.

Lead investigator Michael Schwarzschild, MD, PhD, of Massachusetts General Hospital spoke to MJFF Contributing Editor Dave Iverson about the study and next steps.

ďPreliminary data from the study certainly have been supportive of the potential for slowing down the disease, but a really definitive engagement of that hypothesis requires a much larger trial, and thatís what weíre on the threshold of pursuing here,Ē said Michael.

Subscribe on iTunes for more MJFF Parkinsonís Podcasts.

TAGS: Research Field News, Publications, Press Releases, Podcast, Research News, Massachusetts, Phase II Trial, Research Grants, Treatment, Neuroprotective/Regenerative, Therapies in development, Translational Stage, Clinical Trial

 

 

EXISTING MEMBER?

SIGN IN

Close

New to MJFF?  Register Now

 

 

 

  REMEMBER ME

 

Forgot username/password?

 

  Applying for a grant? Sign in here.

EMAIL TO A FRIEND

Close