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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Understanding LRRK2 Biology, 2009
    Building a LRRK2 Cohort Core Database

    Objective/Rationale
    MJFF is funding the expansion of two international LRRK2 cohorts to gain insight into the relationship of this genetic mutation to Parkinson’s disease.  Within each funded study...

  • MJFF Research Grant, 2009
    A Pre-clinical Alpha-Synuclein Model of Parkinson's Disease

    Objective/Rationale:
    This project will aim to establish the behavioral and neuroanatomical correlates of injecting a viral vector that overexpresses the gene for alpha-synuclein into the brains of non...

  • Clinicopathological Correlations of Parkinson’s Disease, 2009
    Evaluation of the Enteric Nervous System in PD

    Objective/Rationale:
    Gastrointestinal (GI) symptoms (constipation, for example) afflict essentially every PD patient, negatively impact quality of life, and diminish effectiveness of oral medications...

  • Clinicopathological Correlations of Parkinson’s Disease, 2009
    Metabolomic Analysis of Parkinson's Disease Cerebrospinal Fluid

    Objective/Rationale:
    Metabolomic analysis is a state-of-the-art laboratory technique and computerized analysis used to catalog hundreds of the chemical constituents in the brain environment. We will...

  • Clinicopathological Correlations of Parkinson’s Disease, 2009
    Identification of Alpha-synuclein Molecular Forms Correlating with Clinicopathology of Parkinson's Disease

    Objective/Rationale:
    A systematic characterization of alpha-synuclein from human tissue using high-resolution mass spectrometry has not been reported. A detailed study of alpha synuclein modifications...

  • Clinicopathological Correlations of Parkinson’s Disease, 2009
    miRNAs as new therapeutic targets and diagnostic biomarkers of PD

    Objective/Rationale:
    microRNAs are newly recognized, small regulatory molecules, playing important roles in normal functions and disease. However, their roles in Parkinson’s disease are still largely...

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