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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2021
    Dietary Interventions to Slow and Improve Parkinson’s Symptoms by Restructuring the Gut Microbiome and Decreasing Inflammation

    Study Rationale:
    There is a link between the gut and the brain in Parkinson’s disease (PD), and gut bacteria may play an important role. Gut bacteria they affect the bowel mucus barrier, produce...

  • Research Grant, 2021
    Hypoxia (Limiting Oxygen Levels) as a Novel Treatment for Parkinson’s Disease

    Study Rationale:
    Many anecdotes suggest that people with Parkinson’s disease (PD) can experience a marked improvement in symptoms when they travel to the mountains or during flights at high altitude...

  • Target Advancement Program, 2021
    Modulation of Epigenetic Regulator HDAC4 as a Parkinson’s Treatment

    Study Rationale:
    Scientists can take skin cells from people with Parkinson’s disease (PD), turn them into stem cells, and then engineer them into dopamine neurons, the cell type lost in PD. Our...

  • Target Advancement Program, 2021
    Targeting the Neurovascular Unit to Prevent Dissemination and Progression of Parkinson’s Disease

    Study Rationale:    
    The cells residing in the brain are physically separated from the blood stream by the blood-brain barrier, a specialized grouping of cells that reduces transfer from the blood...

  • Target Advancement Program, 2021
    Use of Therapeutic Nanoparticles to Inhibit Toxic Aggregation of Alpha-Synuclein

    Study Rationale:
    A hallmark of Parkinson’s disease (PD) is the abnormal accumulation of clumps of alpha-synuclein in nerve cells. These improperly folded protein clumps contribute to the symptoms of...

  • Therapeutic Pipeline Program, 2021
    Studies to Assess the Potential of Gold “Nanocrystals” for the Treatment of Parkinson’s Disease

    Study Rationale: 
    CNM-Au8 is a new type of nanomedicine that consists of tiny crystals made of pure gold. The multifaceted surface of these gold nanocrystals provides a platform for metabolic...

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