The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2021Impact of TRPML1 Stimulation on Clinical Biomarkers and Synuclein Pathology
Study Rationale: The protein TRPML1 regulates the clearance of cellular debris, including aggregated alpha-synuclein and toxic lipids—a process that is disrupted in Parkinson’s disease (PD). We have...
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Using “Nanobodies” to Prevent Formation of Intracellular Alpha-synuclein Aggregates
Study Rationale: The aggregation of a structurally abnormal form of the protein alpha-synuclein appears to be responsible for the initiation and progression of Parkinson’s disease (PD). In previous...
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Fall 2021 RFP: Outcome Measures, 2022Using RNA from Extracellular Vesicles to Monitor RNA Changes in the Brain
Study Rationale: Our understanding of Parkinson’s disease (PD) would be significantly improved if we had a way to directly monitor disease development and progression in the brain. One approach is to...
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Fall 2021 RFP: Outcome Measures, 2021Exploring the Role of Faulty Protein Degradation as a Cause of Parkinson’s Disease
Study Rationale: For the brain to work efficiently, its cells have systems to clear out old proteins that are no longer needed or functional. When these protein-clearing systems fail, old proteins...
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Fall 2021 RFP: Expanding Biological Understanding of PD, 2021Characterizing the Impact of a Protective LRRK2 Variant on Biochemical and Cellular Function
Study Rationale: The LRRK2 gene is one of the most important genes involved in increasing the risk of Parkinson’s disease (PD). Changes in the gene, called mutations, can cause people to develop PD –...
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Research Grant, 2021Evaluation of Digital Mobility Data to Identify Individuals at Risk of Developing Parkinson’s Disease
Study Rationale: Gait disturbances play a major role in the motor manifestation of Parkinson’s disease (PD). Traditional clinical assessments aimed at measuring motor deficits do not sufficiently...
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Our funding programs support basic, translational and clinical research from academia and industry.