The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Novel Hypotheses in Parkinson's Disease, 2010Identifying and Localizing Toxic Oligomeric A-Syn with Morphology Specific Nanobodies
Objective/Rationale:
Aggregation and deposition of the protein, a-synuclein (a-syn), has been strongly correlated with PD and other related neurodegenerative disorders. The a-syn protein occurs in a... -
Pharmacodynamic Biomarkers of LRRK2 Activity, 2010Determining Pharmacodynamic Biomarkers of LRRK2 Activity in Lymphocytes
Objective/Rationale:
Therapeutic strategies targeting aberrant LRRK2 activity hold great promise for the treatment of familial LRRK2 mutant and perhaps idiopathic PD. Development of pharmacodynamic... -
MJFF Research Grant, 2010Physiological and Pathological Implications of the Unique Subcellular Distribution of LRRK2
Objective/Rationale:
Mutations in the LRRK2 gene are now recognized as the most common genetic cause of Parkinson’s disease, responsible for not only several inherited forms of this movement disorder... -
MJFF Research Grant, 2010Validation of Enzymatic Activity and Neuropathology in G2019S LRRK2-induced Dopaminergic Neurodegeneration in a Pre-clinical Model of Parkinson's Disease
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial and sporadic Parkinson’s disease. Familial LRRK2 mutations induce neuronal toxicity in vitro. Reliable pre-clinical... -
MJFF Research Grant, 2010Parkinson's Disease NeuroEPIC: A Study of Genes and the Environment
Objective/Rationale:
We will take advantage of the large European Prospective Investigation in Cancer (EPIC), a unique resource involving almost 500,000 participants from 10 European countries, with... -
Novel Approaches to Drug Discovery, 2010Optimizing Metalloporphryins for Clinical Development Supplement
Promising Outcomes of Original Grant:
The overall goal of this ongoing proposal is to determine if a newly developed series of metalloporphyrins designed to penetrate blood brain barrier shows promise...
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Our funding programs support basic, translational and clinical research from academia and industry.