The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Clinical Intervention Awards, 2008Simvastatin for the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease
Objective/Rationale:
Levodopa-induced dyskinesias are caused by an increased response of dopamine receptors to dopamine in the striatum. Among other intracellular pathways, the MAP kinase signaling... -
Clinical Intervention Awards, 2008Phase II Study of Isradipine as a Disease-modifying Agent in Early Parkinson's Disease
Objective/Rationale:
Isradipine, a drug approved by the FDA for treatment of high blood pressure, has been found to be neuroprotective in pre-clinical models of parkinsonism. The objective of this... -
Therapeutics Development Initiative -- Academic Track, 2008miRNA-based Therapy for Parkinson's Disease
Objective/Rationale:
A central pathological finding associated with PD is the presence of distinctive, abnormal aggregates in brain cells typically lost in PD, termed dopamine neurons. These... -
Therapeutics Development Initiative -- Academic Track, 2008Pre-clinical characterization of 5-HT1A/1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
Objective/Rationale:
Levodopa, which is the most commonly used medication for patients with Parkinson's disease (PD), can cause, as the disease progresses, debilitating involuntary movements, so... -
Rapid Response Innovation Awards, 2007Autophagy in Dopamine Neurons: Clearance of Alpha-synuclein and Neuroprotection
The central hypothesis for the cellular mechanism of Parkinson’s disease is the toxic accumulation of alpha-synuclein, dysfunctional protein clearance and oxidative stress collectively leading to the...
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PD Subtypes, 2007Evaluating Novel Predictors of Parkinson's Disease Progression
How the symptoms of Parkinson’s disease progress varies from patient to patient, and it is hard to predict which patients will progress more quickly than others. One way to figure this out is to look...
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Our funding programs support basic, translational and clinical research from academia and industry.